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| Career Strikeouts Leaderboard | |
| * - Indicates Hall of Fame Bold - Indicates active player |
| Rank | Player | Strikeouts | PA | Years | Single Season Leaderboard |
| 1. | Carlo Barrera | 1832 | 8139 | 2007-2020 | |
| 2. | Paul Haruki | 1824 | 9098 | 2007-2021 | |
| 3. | Aaron Baldiris | 1731 | 6810 | 2007-2019 | |
| 4. | Casimiro Diaz | 1696 | 7919 | 2007-2021 | |
| 5. | Richard Sheldon | 1657 | 9146 | 2007-2021 | |
| 6. | Prince Gilbreath | 1610 | 7145 | 2008-2021 | |
| 7. | Wilson Betemit | 1547 | 8055 | 2007-2020 | |
| 8. | Hollis Defazio | 1528 | 7732 | 2010-2021 | |
| 9. | Nick Swisher | 1480 | 7853 | 2007-2018 | |
| 10. | William Lamberth | 1477 | 9230 | 2007-2021 | |
| 11. | Johnny Miller | 1450 | 8765 | 2008-2021 | |
| 12. | Aaron Braza | 1422 | 7218 | 2007-2018 | |
| 13. | Chris Snavely | 1404 | 6173 | 2007-2020 | |
| 14. | Carlos Beltran | 1403 | 6443 | 2007-2016 | |
| 15. | Kelly Johnson | 1374 | 7195 | 2007-2020 | |
| 16. | Rickie Weeks | 1339 | 7443 | 2007-2018 | |
| 17. | Damian James | 1326 | 6909 | 2010-2021 | |
| 18. | Keith Pollock | 1325 | 6716 | 2010-2021 | |
| 19. | Brad Nelson | 1314 | 6147 | 2007-2019 | |
| 20. | Matt Murton | 1299 | 6951 | 2007-2017 | |
| 21. | Mickey Hall | 1293 | 6505 | 2010-2020 | |
| 22. | Mike O'Keefe | 1270 | 5813 | 2007-2017 | |
| 23. | Darwin Alexander | 1265 | 6534 | 2007-2018 | |
| 24. | Manuel Pardo | 1241 | 5401 | 2007-2018 | |
| 25. | Brian Specht | 1226 | 7917 | 2007-2019 | |
| 26. | Lance Berkman * | 1220 | 5621 | 2007-2016 | |
| 27. | Rueben Manzo | 1217 | 7705 | 2010-2021 | |
| 28. | Joe Crede | 1206 | 4849 | 2007-2014 | |
| 29. | Wily Mo Pena | 1194 | 4748 | 2007-2016 | |
| 30. | Joseph Shine | 1188 | 4981 | 2010-2021 | |
| 31. | Ivan Lawhon | 1166 | 6750 | 2007-2018 | |
| 32. | Edward Caples | 1161 | 4491 | 2012-2021 | |
| 33. | Jose Montero | 1159 | 5801 | 2010-2021 | |
| 34. | Grady Sizemore | 1148 | 8463 | 2007-2020 | |
| 35. | Nathanael Sasser | 1145 | 5834 | 2008-2018 | |
| 36. | Jack Cust | 1143 | 4624 | 2007-2016 | |
| 37. | Kenneth Johnston | 1133 | 4698 | 2010-2020 | |
| 38. | Jack Mickelsen | 1131 | 4812 | 2012-2021 | |
| 39. | Kyle Walker | 1125 | 6394 | 2010-2021 | |
| 40. | Johnnie Harley | 1124 | 6619 | 2011-2021 | |
| 41. | Matt Macri | 1111 | 7607 | 2007-2020 | |
| Harold Gervais | 1111 | 5463 | 2012-2020 | ||
| 43. | Michael Rogers | 1110 | 6089 | 2009-2021 | |
| 44. | Michael Garciaparra | 1102 | 6736 | 2009-2020 | |
| 45. | Albert Pujols * | 1096 | 7874 | 2007-2018 | |
| 46. | Edward Beaudoin | 1092 | 4587 | 2008-2021 | |
| 47. | Toshiya Nakashima | 1085 | 6600 | 2007-2019 | |
| 48. | Michael Doyle | 1083 | 7123 | 2009-2021 | |
| 49. | Anthony Gwynn | 1069 | 7637 | 2007-2021 | |
| J.D. Closser | 1069 | 4627 | 2007-2016 | ||
| 51. | Omar Infante | 1066 | 6921 | 2007-2020 | |
| 52. | Chris Lubanski | 1063 | 7595 | 2010-2021 | |
| 53. | Angel Molina | 1042 | 6236 | 2007-2018 | |
| Kevin Sidhu | 1042 | 5480 | 2007-2018 | ||
| 55. | Chris Snelling | 1036 | 8106 | 2007-2020 | |
| 56. | Juan Hernandez | 1020 | 5574 | 2012-2021 | |
| 57. | Juan Gonzalez | 1018 | 6134 | 2009-2020 | |
| 58. | Renato Fajardo | 1008 | 6241 | 2010-2021 | |
| 59. | Daniel Kessler | 1006 | 5989 | 2010-2021 | |
| 60. | Lee Tacker | 1005 | 6166 | 2007-2017 | |
| 61. | Yoshitomo Tani | 1001 | 6844 | 2007-2017 | |
| 62. | Travis Hafner | 998 | 4941 | 2007-2015 | |
| 63. | Gabe Gross | 997 | 4255 | 2007-2017 | |
| 64. | Geronimo Rosales | 996 | 6747 | 2010-2021 | |
| 65. | Preston Wilson | 995 | 4762 | 2007-2014 | |
| 66. | Francisco Fernandes | 991 | 5338 | 2011-2021 | |
| 67. | Bradley Small | 988 | 6338 | 2011-2021 | |
| 68. | Adam Dunn | 986 | 4396 | 2007-2015 | |
| 69. | Stuart Hamilton | 977 | 4020 | 2014-2021 | |
| 70. | Brett Tamburino | 976 | 4286 | 2008-2018 | |
| 71. | Barney Cobas | 972 | 5175 | 2012-2021 | |
| 72. | Charlie Rogers | 971 | 4243 | 2008-2019 | |
| 73. | Ruben Domingo | 965 | 5063 | 2012-2021 | |
| John Arrington | 965 | 4310 | 2010-2021 | ||
| 75. | Leonardo Cepeda | 964 | 4877 | 2013-2021 | |
| 76. | Andre Henriques | 962 | 4389 | 2010-2020 | |
| Tim Moss | 962 | 5296 | 2007-2018 | ||
| 78. | Jarrod Saltalamacchia | 958 | 5970 | 2008-2019 | |
| 79. | Manuel Melo | 948 | 6800 | 2007-2018 | |
| 80. | Ryan Howard | 938 | 4349 | 2007-2015 | |
| 81. | Ferdin Tejada | 933 | 5972 | 2010-2020 | |
| 82. | Robinson Cano | 928 | 6631 | 2008-2020 | |
| 83. | Brad Wilkerson | 926 | 4682 | 2007-2014 | |
| 84. | Andruw Jones * | 923 | 4087 | 2007-2014 | |
| 85. | Miguel Almanzar | 919 | 4631 | 2010-2020 | |
| Laynce Nix | 919 | 5614 | 2007-2017 | ||
| Alfonso Soriano | 919 | 3812 | 2007-2014 | ||
| 88. | Corey Patterson | 918 | 5698 | 2007-2017 | |
| 89. | Josh Phelps | 917 | 3896 | 2007-2013 | |
| 90. | Merlin Justice | 916 | 5583 | 2010-2019 | |
| 91. | C.J. Bressoud | 915 | 5222 | 2011-2021 | |
| 92. | Dylan Lammond | 907 | 5402 | 2013-2021 | |
| 93. | Anderson Machado | 897 | 5495 | 2007-2016 | |
| 94. | Tony Blanco | 892 | 3882 | 2008-2017 | |
| 95. | Antonio Carballosa | 888 | 4031 | 2008-2019 | |
| 96. | Carlos Quentin | 886 | 6771 | 2010-2020 | |
| 97. | Gabriel Crow | 882 | 5878 | 2010-2021 | |
| 98. | Samuel Gladstone | 875 | 5598 | 2011-2021 | |
| Juan Vazquez | 875 | 5183 | 2010-2020 | ||
| 100. | Carlos Pena | 874 | 5963 | 2007-2016 |
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