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| Single-Season Singles Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | Singles | PA | Year | Career Leaderboard |
| 1. | Jason Tyner | 197 | 693 | 2009 | |
| 2. | Ferdin Tejada | 186 | 669 | 2015 | |
| 3. | Anthony Gwynn | 183 | 670 | 2019 | |
| 4. | Felix Veach | 180 | 656 | 2021 | |
| 5. | Ferdin Tejada | 174 | 680 | 2013 | |
| 6. | Jose Juarez | 172 | 682 | 2020 | |
| 7. | Robert Cervantes | 171 | 679 | 2018 | |
| 8. | Alejandro Machado | 167 | 661 | 2015 | |
| Omar Infante | 167 | 670 | 2009 | ||
| 10. | Leopoldo Arguello | 166 | 699 | 2017 | |
| Daniel Perales | 166 | 675 | 2015 | ||
| 12. | Felix Veach | 164 | 681 | 2020 | |
| Johnnie Heuer | 164 | 681 | 2020 | ||
| Alfonso Romero | 164 | 671 | 2019 | ||
| Christopher McAuslane | 164 | 699 | 2018 | ||
| 16. | Grady Sizemore | 163 | 683 | 2016 | |
| 17. | Jose Juarez | 162 | 668 | 2019 | |
| Alejandro Machado | 162 | 680 | 2018 | ||
| Josh Wilson | 162 | 677 | 2013 | ||
| Chris Lubanski | 162 | 689 | 2010 | ||
| 21. | Robert Cervantes | 161 | 685 | 2017 | |
| 22. | Barney Cobas | 160 | 747 | 2018 | |
| Ferdin Tejada | 160 | 646 | 2014 | ||
| Cristian Guerrero | 160 | 698 | 2013 | ||
| 25. | Christopher McAuslane | 159 | 712 | 2019 | |
| Manuel Melo | 159 | 714 | 2017 | ||
| Ferdin Tejada | 159 | 661 | 2017 | ||
| Yoshitomo Tani | 159 | 704 | 2016 | ||
| Alejandro Machado | 159 | 681 | 2007 | ||
| 30. | Manuel Heredia | 158 | 657 | 2021 | |
| Manuel Heredia | 158 | 668 | 2020 | ||
| Dernell Stenson | 158 | 651 | 2011 | ||
| Yoshitomo Tani | 158 | 684 | 2009 | ||
| 34. | George Mulhern | 157 | 646 | 2021 | |
| Dave Alard | 157 | 682 | 2019 | ||
| Felix Veach | 157 | 670 | 2019 | ||
| Jose Juarez | 157 | 680 | 2018 | ||
| Antron Seiber | 157 | 649 | 2013 | ||
| Richard Lewis | 157 | 670 | 2009 | ||
| Anthony Gwynn | 157 | 655 | 2009 | ||
| 41. | Chris Lubanski | 156 | 680 | 2013 | |
| Dominic Rich | 156 | 670 | 2008 | ||
| 43. | George Mulhern | 155 | 620 | 2019 | |
| Robert Harris | 155 | 655 | 2018 | ||
| Alejandro Machado | 155 | 674 | 2016 | ||
| Jason Romano | 155 | 650 | 2015 | ||
| Jarrod Saltalamacchia | 155 | 553 | 2010 | ||
| 48. | Alfonso Fraile | 154 | 644 | 2021 | |
| Franky Espada | 154 | 692 | 2017 | ||
| Ferdin Tejada | 154 | 668 | 2012 | ||
| Juan Pierre | 154 | 562 | 2012 | ||
| Chris Delacruz | 154 | 683 | 2011 | ||
| Tony Torcato | 154 | 667 | 2008 | ||
| 54. | Luis Martin | 153 | 666 | 2020 | |
| Robinson Cano | 153 | 646 | 2017 | ||
| Robert Cervantes | 153 | 652 | 2014 | ||
| Josh Wilson | 153 | 647 | 2014 | ||
| 58. | Jose Juarez | 152 | 677 | 2021 | |
| Luciano Cifonte | 152 | 647 | 2020 | ||
| Peter Harnois | 152 | 677 | 2019 | ||
| Leopoldo Arguello | 152 | 620 | 2019 | ||
| Chris Lubanski | 152 | 696 | 2016 | ||
| Robert Cervantes | 152 | 664 | 2016 | ||
| Omar Infante | 152 | 694 | 2012 | ||
| Luis Castillo | 152 | 659 | 2009 | ||
| 66. | Francisco Pedroza | 151 | 701 | 2020 | |
| Michael Smithson | 151 | 656 | 2020 | ||
| Johnnie Gardner | 151 | 648 | 2019 | ||
| Jesus Gonzalez | 151 | 671 | 2018 | ||
| Alejandro Machado | 151 | 617 | 2017 | ||
| Robert Harris | 151 | 670 | 2016 | ||
| Matt Moses | 151 | 662 | 2015 | ||
| Keith Pollock | 151 | 701 | 2014 | ||
| Antron Seiber | 151 | 654 | 2014 | ||
| Kevin Youkilis | 151 | 666 | 2010 | ||
| Josh Wilson | 151 | 668 | 2008 | ||
| 77. | Luciano Cifonte | 150 | 658 | 2021 | |
| Lucas Garcia | 150 | 700 | 2019 | ||
| Jake Blalock | 150 | 683 | 2017 | ||
| Irwin Centeno | 150 | 644 | 2016 | ||
| Scott Neuberger | 150 | 646 | 2011 | ||
| Alejandro Machado | 150 | 615 | 2009 | ||
| 83. | Lucas Garcia | 149 | 641 | 2018 | |
| Ferdin Tejada | 149 | 662 | 2016 | ||
| Bradley Small | 149 | 689 | 2014 | ||
| Robert Cervantes | 149 | 624 | 2013 | ||
| Tony Richie | 149 | 615 | 2013 | ||
| Juan Waites | 149 | 693 | 2012 | ||
| 89. | George Mulhern | 148 | 680 | 2020 | |
| Florentino Pina | 148 | 662 | 2018 | ||
| Roger Bernadina | 148 | 652 | 2018 | ||
| Everett Stadler | 148 | 637 | 2018 | ||
| Tony Torcato | 148 | 633 | 2014 | ||
| Ramon Castro | 148 | 665 | 2013 | ||
| Albert Pujols * | 148 | 639 | 2011 | ||
| Jose Flores | 148 | 672 | 2008 | ||
| Tony Acevedo | 148 | 642 | 2008 | ||
| Luis Castillo | 148 | 588 | 2008 | ||
| 99. | Lucas Garcia | 147 | 718 | 2021 | |
| Johnnie Heuer | 147 | 694 | 2021 |
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