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| Single-Season Hits Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | Hits | PA | Year | Career Leaderboard |
| 1. | Jason Tyner | 237 | 693 | 2009 | |
| 2. | Robert Cervantes | 231 | 679 | 2018 | |
| 3. | Robert Cervantes | 227 | 685 | 2017 | |
| 4. | Chris Lubanski | 223 | 689 | 2010 | |
| 5. | Anthony Gwynn | 222 | 670 | 2019 | |
| 6. | Chris Lubanski | 220 | 680 | 2013 | |
| 7. | Felix Veach | 217 | 656 | 2021 | |
| 8. | Alfonso Romero | 213 | 671 | 2019 | |
| Josh Wilson | 213 | 677 | 2013 | ||
| 10. | Jesus Gonzalez | 212 | 671 | 2018 | |
| 11. | Jose Juarez | 211 | 682 | 2020 | |
| Steven Maccaskill | 211 | 670 | 2016 | ||
| Ferdin Tejada | 211 | 680 | 2013 | ||
| Tony Torcato | 211 | 667 | 2008 | ||
| 15. | Alfonso Fraile | 210 | 644 | 2021 | |
| 16. | Florentino Pina | 209 | 663 | 2020 | |
| Florentino Pina | 209 | 662 | 2018 | ||
| Leopoldo Arguello | 209 | 699 | 2017 | ||
| Omar Infante | 209 | 670 | 2009 | ||
| 20. | Tony Miller | 207 | 675 | 2011 | |
| 21. | Chris Lubanski | 206 | 696 | 2016 | |
| Ferdin Tejada | 206 | 669 | 2015 | ||
| Matt Cepicky | 206 | 641 | 2009 | ||
| 24. | Robert Harris | 205 | 670 | 2016 | |
| 25. | Albert Pujols * | 204 | 667 | 2015 | |
| Shin-Soo Choo | 204 | 707 | 2011 | ||
| 27. | George Mulhern | 203 | 646 | 2021 | |
| Felix Veach | 203 | 681 | 2020 | ||
| Christopher Shoulders | 203 | 706 | 2019 | ||
| Peter Harnois | 203 | 677 | 2019 | ||
| Tony Torcato | 203 | 674 | 2012 | ||
| Albert Pujols * | 203 | 639 | 2011 | ||
| Omar Infante | 203 | 650 | 2010 | ||
| 34. | Francisco Pedroza | 202 | 701 | 2020 | |
| Barney Cobas | 202 | 747 | 2018 | ||
| Yoshitomo Tani | 202 | 684 | 2009 | ||
| 37. | Rueben Manzo | 201 | 673 | 2019 | |
| Christopher McAuslane | 201 | 699 | 2018 | ||
| Robert Cervantes | 201 | 664 | 2016 | ||
| Albert Pujols * | 201 | 643 | 2013 | ||
| Chad Tracy | 201 | 690 | 2012 | ||
| Henry Mateo | 201 | 652 | 2011 | ||
| 43. | John Williams | 200 | 664 | 2021 | |
| Manuel Leon | 200 | 661 | 2019 | ||
| Manuel Melo | 200 | 714 | 2017 | ||
| Cristian Guerrero | 200 | 698 | 2013 | ||
| Renato Fajardo | 200 | 657 | 2012 | ||
| Bobby Crosby | 200 | 693 | 2011 | ||
| 49. | George Mulhern | 199 | 680 | 2020 | |
| Bradley Small | 199 | 689 | 2014 | ||
| Chris Lubanski | 199 | 706 | 2012 | ||
| Robert Cervantes | 199 | 642 | 2012 | ||
| Josh Wilson | 199 | 668 | 2008 | ||
| 54. | George Mulhern | 198 | 620 | 2019 | |
| Daniel Perales | 198 | 675 | 2015 | ||
| Matt Moses | 198 | 662 | 2015 | ||
| Tony Torcato | 198 | 633 | 2014 | ||
| Nick Swisher | 198 | 712 | 2013 | ||
| Michael Garciaparra | 198 | 652 | 2012 | ||
| Carlo Barrera | 198 | 698 | 2010 | ||
| Anthony Gwynn | 198 | 655 | 2009 | ||
| 62. | Christopher McAuslane | 197 | 712 | 2019 | |
| Juan Hernandez | 197 | 683 | 2019 | ||
| Yoshitomo Tani | 197 | 718 | 2015 | ||
| Alejandro Machado | 197 | 661 | 2015 | ||
| Robert Cervantes | 197 | 652 | 2014 | ||
| Albert Pujols * | 197 | 637 | 2014 | ||
| Nathan Haynes | 197 | 645 | 2009 | ||
| 69. | Steven Maccaskill | 196 | 669 | 2021 | |
| Connor Macgrime | 196 | 642 | 2021 | ||
| Rueben Manzo | 196 | 629 | 2021 | ||
| Leopoldo Arguello | 196 | 620 | 2019 | ||
| Everett Stadler | 196 | 637 | 2018 | ||
| Rueben Manzo | 196 | 640 | 2017 | ||
| Nathan Haynes | 196 | 672 | 2015 | ||
| Adan Guerra | 196 | 656 | 2013 | ||
| Victor Martinez | 196 | 587 | 2011 | ||
| Matt Macri | 196 | 659 | 2010 | ||
| Mark Kotsay | 196 | 675 | 2008 | ||
| 80. | Keith Pollock | 195 | 654 | 2021 | |
| Florentino Pina | 195 | 660 | 2019 | ||
| Keith Pollock | 195 | 670 | 2018 | ||
| Franky Espada | 195 | 692 | 2017 | ||
| Albert Pujols * | 195 | 664 | 2017 | ||
| Robinson Cano | 195 | 646 | 2017 | ||
| Keith Pollock | 195 | 663 | 2016 | ||
| Omar Infante | 195 | 694 | 2012 | ||
| Carlos Beltran | 195 | 653 | 2010 | ||
| Preston Wilson | 195 | 643 | 2009 | ||
| Jason Giambi | 195 | 658 | 2008 | ||
| 91. | Christopher Shoulders | 194 | 747 | 2021 | |
| Jason Triggs | 194 | 654 | 2021 | ||
| Jesus Gonzalez | 194 | 676 | 2020 | ||
| Manuel Heredia | 194 | 668 | 2020 | ||
| Jose Juarez | 194 | 680 | 2018 | ||
| Hollis Defazio | 194 | 685 | 2017 | ||
| Gabriel Crow | 194 | 679 | 2016 | ||
| Ramon Castro | 194 | 665 | 2013 | ||
| Dernell Stenson | 194 | 651 | 2011 | ||
| Victor Martinez | 194 | 617 | 2010 |
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