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| Single-Season Strikeouts Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | Strikeouts | PA | Year | Career Leaderboard |
| 1. | Preston Wilson | 191 | 681 | 2007 | |
| 2. | Joe Borchard | 189 | 632 | 2007 | |
| 3. | Aaron Baldiris | 188 | 741 | 2009 | |
| 4. | Joe Crede | 183 | 646 | 2009 | |
| 5. | Andy Phillips | 179 | 677 | 2013 | |
| 6. | Nick Swisher | 175 | 707 | 2017 | |
| 7. | Jonny Gomes | 174 | 604 | 2007 | |
| 8. | Stuart Cockburn | 173 | 673 | 2021 | |
| Joe Crede | 173 | 647 | 2010 | ||
| 10. | Nelson Dones | 172 | 694 | 2019 | |
| Prince Gilbreath | 172 | 633 | 2015 | ||
| Aaron Baldiris | 172 | 630 | 2015 | ||
| 13. | Nate McLouth | 169 | 671 | 2016 | |
| Aaron Baldiris | 169 | 609 | 2007 | ||
| 15. | Edward Caples | 168 | 651 | 2017 | |
| Rickie Weeks | 168 | 702 | 2016 | ||
| Wily Mo Pena | 168 | 616 | 2013 | ||
| Craig Monroe | 168 | 604 | 2011 | ||
| Carlos Beltran | 168 | 681 | 2007 | ||
| Joe Crede | 168 | 623 | 2007 | ||
| 21. | Aaron Baldiris | 167 | 602 | 2011 | |
| Alfonso Soriano | 167 | 637 | 2007 | ||
| Rob Mackowiak | 167 | 631 | 2007 | ||
| 24. | Casimiro Diaz | 165 | 584 | 2020 | |
| Carlo Barrera | 165 | 637 | 2015 | ||
| Steve Smitherman | 165 | 635 | 2010 | ||
| Alex Rodriguez * | 165 | 665 | 2007 | ||
| 28. | Stuart Hamilton | 164 | 606 | 2016 | |
| 29. | Stuart Hamilton | 163 | 716 | 2019 | |
| Stephen Maccrouther | 163 | 680 | 2017 | ||
| Mike O'Keefe | 163 | 637 | 2016 | ||
| Wily Mo Pena | 163 | 605 | 2011 | ||
| Ray Durham | 163 | 668 | 2008 | ||
| Jayson Werth | 163 | 604 | 2007 | ||
| Glenn Williams | 163 | 555 | 2007 | ||
| 36. | Adam Dunn | 162 | 661 | 2012 | |
| Pat Burrell | 162 | 692 | 2008 | ||
| Kevin Mench | 162 | 616 | 2007 | ||
| 39. | Nelson Dones | 161 | 663 | 2018 | |
| Manuel Pardo | 161 | 634 | 2015 | ||
| Carlo Barrera | 161 | 668 | 2012 | ||
| Aaron Baldiris | 161 | 656 | 2008 | ||
| 43. | Carlos Beltran | 160 | 576 | 2016 | |
| Ryan Howard | 160 | 628 | 2009 | ||
| Darwin Alexander | 160 | 664 | 2007 | ||
| 46. | Steven Au | 159 | 625 | 2021 | |
| Chris Snavely | 159 | 620 | 2019 | ||
| Gabriel Seo | 159 | 633 | 2018 | ||
| Kenneth Johnston | 159 | 614 | 2018 | ||
| Darwin Alexander | 159 | 686 | 2009 | ||
| Darwin Alexander | 159 | 666 | 2008 | ||
| Prince Gilbreath | 159 | 663 | 2008 | ||
| 53. | Freeman Pace | 158 | 686 | 2020 | |
| Prince Gilbreath | 158 | 657 | 2019 | ||
| Mickey Hall | 158 | 685 | 2016 | ||
| Miguel Almanzar | 158 | 636 | 2016 | ||
| Ken Harvey | 158 | 663 | 2014 | ||
| Adam Dunn | 158 | 684 | 2013 | ||
| Troy Glaus | 158 | 651 | 2007 | ||
| 60. | Prince Gilbreath | 157 | 650 | 2016 | |
| Luis Davila | 157 | 631 | 2015 | ||
| Wilson Betemit | 157 | 610 | 2015 | ||
| 63. | Edward Caples | 156 | 577 | 2018 | |
| Carlo Barrera | 156 | 649 | 2016 | ||
| Irwin Centeno | 156 | 644 | 2016 | ||
| Brett Tamburino | 156 | 563 | 2015 | ||
| Carlo Barrera | 156 | 686 | 2014 | ||
| Andy Phillips | 156 | 624 | 2011 | ||
| Jose Cruz Jr. | 156 | 641 | 2010 | ||
| Richie Sexson | 156 | 605 | 2008 | ||
| 71. | Clair Lavery | 155 | 600 | 2020 | |
| Carlo Barrera | 155 | 665 | 2019 | ||
| Joseph Shine | 155 | 555 | 2010 | ||
| Scott Rolen | 155 | 615 | 2009 | ||
| Carlo Barrera | 155 | 658 | 2008 | ||
| Alfonso Soriano | 155 | 656 | 2008 | ||
| 77. | Stuart Hamilton | 154 | 620 | 2020 | |
| Prince Gilbreath | 154 | 629 | 2017 | ||
| Tony Blanco | 154 | 627 | 2014 | ||
| Mark Bellhorn | 154 | 610 | 2007 | ||
| 81. | Marty Ouimet | 153 | 567 | 2020 | |
| Manuel Pardo | 153 | 602 | 2017 | ||
| Jason Stokes | 153 | 614 | 2016 | ||
| Austin Kearns | 153 | 634 | 2014 | ||
| Jack Cust | 153 | 614 | 2014 | ||
| Paul Haruki | 153 | 669 | 2010 | ||
| Bobby Kielty | 153 | 670 | 2008 | ||
| Pat Burrell | 153 | 600 | 2007 | ||
| Eli Marrero | 153 | 573 | 2007 | ||
| 90. | Ryan Seelye | 152 | 697 | 2021 | |
| Joseph Maxwell | 152 | 641 | 2016 | ||
| Hollis Defazio | 152 | 562 | 2010 | ||
| Derek Jeter | 152 | 685 | 2009 | ||
| Andruw Jones * | 152 | 629 | 2009 | ||
| Jack Cust | 152 | 637 | 2008 | ||
| Jim Edmonds | 152 | 613 | 2007 | ||
| 97. | James Calhoon | 151 | 648 | 2020 | |
| Mike O'Keefe | 151 | 650 | 2015 | ||
| Aaron Baldiris | 151 | 604 | 2014 | ||
| Casimiro Diaz | 151 | 596 | 2007 |
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