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| Single-Season RBIs Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | RBIs | PA | Year | Career Leaderboard |
| 1. | Alex Rodriguez * | 180 | 669 | 2008 | |
| 2. | Juan Rivera | 145 | 673 | 2010 | |
| 3. | Nick Swisher | 143 | 712 | 2013 | |
| Bill Kolar | 143 | 685 | 2011 | ||
| 5. | Lance Berkman * | 142 | 681 | 2007 | |
| 6. | Ryan Howard | 141 | 667 | 2013 | |
| 7. | Michael Garciaparra | 140 | 680 | 2013 | |
| Jorge Cortes | 140 | 648 | 2012 | ||
| Carlo Barrera | 140 | 698 | 2010 | ||
| Michael Garciaparra | 140 | 676 | 2010 | ||
| Chris Duncan | 140 | 660 | 2010 | ||
| Bill Kolar | 140 | 689 | 2009 | ||
| Kevin Mench | 140 | 628 | 2009 | ||
| Pat Burrell | 140 | 692 | 2008 | ||
| Josh Phelps | 140 | 576 | 2008 | ||
| 16. | Michael Peck | 138 | 669 | 2020 | |
| Matt Macri | 138 | 659 | 2010 | ||
| 18. | Steven Maccaskill | 137 | 672 | 2019 | |
| Robert Cervantes | 137 | 685 | 2017 | ||
| 20. | Tom Chisholm | 135 | 671 | 2021 | |
| Florentino Pina | 135 | 663 | 2020 | ||
| Carlos Quentin | 135 | 685 | 2013 | ||
| Michael Garciaparra | 135 | 630 | 2011 | ||
| 24. | Joe Crede | 133 | 646 | 2009 | |
| 25. | Christopher Rode | 132 | 659 | 2015 | |
| Lance Berkman * | 132 | 611 | 2008 | ||
| 27. | Damian James | 131 | 650 | 2019 | |
| Carlos Quentin | 131 | 616 | 2014 | ||
| 29. | Juan Mariscal | 130 | 657 | 2020 | |
| Michael Garciaparra | 130 | 652 | 2012 | ||
| Paul Haruki | 130 | 669 | 2010 | ||
| 32. | Hollis Defazio | 129 | 685 | 2017 | |
| Kevin Sidhu | 129 | 670 | 2013 | ||
| Brandon Phillips | 129 | 642 | 2013 | ||
| Carlos Pena | 129 | 660 | 2010 | ||
| Lance Berkman * | 129 | 602 | 2009 | ||
| Nick Swisher | 129 | 665 | 2008 | ||
| 38. | Michael Garciaparra | 128 | 666 | 2015 | |
| Nick Green | 128 | 636 | 2010 | ||
| 40. | Carlos Quentin | 127 | 713 | 2012 | |
| Carlos Pena | 127 | 659 | 2009 | ||
| 42. | Ivan Lawhon | 126 | 642 | 2013 | |
| Prince Gilbreath | 126 | 649 | 2012 | ||
| Chris Duncan | 126 | 648 | 2011 | ||
| Alex Rodriguez * | 126 | 666 | 2010 | ||
| Alex Rodriguez * | 126 | 665 | 2007 | ||
| 47. | William Lamberth | 125 | 672 | 2019 | |
| Johnnie Harley | 125 | 636 | 2014 | ||
| Justin Knoedler | 125 | 595 | 2013 | ||
| Michael Restovich | 125 | 593 | 2010 | ||
| Todd Helton * | 125 | 597 | 2008 | ||
| 52. | Steven Maccaskill | 124 | 669 | 2021 | |
| Joel Echague | 124 | 680 | 2019 | ||
| Michael Tucker | 124 | 633 | 2009 | ||
| Eric Chavez | 124 | 608 | 2009 | ||
| Ryan Howard | 124 | 634 | 2008 | ||
| Troy Glaus | 124 | 651 | 2007 | ||
| 58. | Brandon Phillips | 123 | 669 | 2014 | |
| Mark Teixeira | 123 | 684 | 2013 | ||
| Travis Hafner | 123 | 671 | 2009 | ||
| Bill Kolar | 123 | 666 | 2008 | ||
| 62. | Francisco Fernandes | 122 | 635 | 2019 | |
| Carlos Pena | 122 | 667 | 2013 | ||
| Justin Morneau | 122 | 691 | 2011 | ||
| Vladimir Guerrero | 122 | 673 | 2009 | ||
| 66. | Prince Gilbreath | 121 | 614 | 2018 | |
| Steven Maccaskill | 121 | 677 | 2017 | ||
| Dallas McPherson | 121 | 682 | 2009 | ||
| Albert Pujols * | 121 | 658 | 2009 | ||
| 70. | Richard Freeze | 120 | 737 | 2021 | |
| Paul Haruki | 120 | 651 | 2021 | ||
| Johnnie Harley | 120 | 659 | 2015 | ||
| Michael Garciaparra | 120 | 683 | 2014 | ||
| Wilson Betemit | 120 | 670 | 2013 | ||
| Wily Mo Pena | 120 | 605 | 2011 | ||
| Joe Crede | 120 | 647 | 2010 | ||
| Miguel Tejada | 120 | 646 | 2008 | ||
| 78. | Fernando Gonzalez | 119 | 612 | 2019 | |
| Albert Pujols * | 119 | 643 | 2013 | ||
| Chad Tracy | 119 | 628 | 2011 | ||
| Matt Cepicky | 119 | 612 | 2010 | ||
| Justin Morneau | 119 | 684 | 2009 | ||
| Carlo Barrera | 119 | 658 | 2008 | ||
| 84. | Michael Peck | 118 | 643 | 2021 | |
| Lukasz Starszewski | 118 | 634 | 2021 | ||
| Harold Gervais | 118 | 613 | 2017 | ||
| Aaron Braza | 118 | 672 | 2014 | ||
| Carlos Beltran | 118 | 653 | 2010 | ||
| Kevin Mench | 118 | 616 | 2007 | ||
| 90. | Christopher Rode | 117 | 615 | 2020 | |
| Kyle Walker | 117 | 660 | 2016 | ||
| Carlo Barrera | 117 | 668 | 2012 | ||
| Wily Mo Pena | 117 | 657 | 2010 | ||
| Albert Pujols * | 117 | 650 | 2010 | ||
| Wily Mo Pena | 117 | 581 | 2009 | ||
| Justin Morneau | 117 | 672 | 2008 | ||
| Carlos Pena | 117 | 656 | 2007 | ||
| Todd Helton * | 117 | 622 | 2007 | ||
| 99. | Kieran Macleister | 116 | 571 | 2020 | |
| Lukasz Starszewski | 116 | 633 | 2019 |
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